Instance ID10120
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFVGFSY
Bait Uniprot AccessionQ9ERE3
Bait Uniprot IdentifierSGK3_MOUSE
Bait Gene NameSgk3
Bait OrganismMus musculus (Mouse)
Sequence Position482-487
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Classical fluorescence spectroscopy; Protein kinase assay; Mutation analysis
Interaction ID20120
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14604990
CommentsCISK (Sgk3) and PDK-1 interact in a phosphorylation-dependent manner through the hydrophobic motif of Sgk3 and the PIF-binding pocket of PDK1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)