Instance ID10121
Regular ExpressionFxx[FWY][DE][FY]
Motif InstanceFRDFDY
Bait Uniprot AccessionQ16513
Bait Uniprot IdentifierPKN2_HUMAN
Bait Gene NamePKN2
Bait OrganismHomo sapiens (Human)
Sequence Position974-979
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Affinity chromatography technology; Western blot; Mutation analysis; Y2H; Pull down; SPR; Competition binding
Interaction ID20121
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16219676, 10698939, 10764742
Comments"The hydrophobic motif in the PKC-related kinase, PRK2 (or PKN2), which acts as a ""docking site"" for recruitment of PDK1 and is essential for its phosphorylation by PDK1 in cells"

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)