Instance ID10133
Regular ExpressionFxDxF
Motif InstanceFEDNF
Bait Uniprot AccessionO08838
Bait Uniprot IdentifierAMPH_RAT
Bait Gene NameAmph
Bait OrganismRattus norvegicus (Rat)
Sequence Position324-328
Critical ResiduesP1; P3; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC; X-ray crystallography; Pull down; Mutation analysis
Interaction ID20133
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha-2
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17986641
CommentsThe FXDXF motif in rat Amphiphysin I that is the main determinant for the high affinity interaction with the C-terminal appendage domain of mouse Alpha-adaptin C

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)