Instance ID10159
Regular ExpressionxRxxLxx[LIVM]x
Motif InstanceHRKHLQEIP
Bait Uniprot AccessionQ13309
Bait Uniprot IdentifierSKP2_HUMAN
Bait Gene NameSKP2
Bait OrganismHomo sapiens (Human)
Sequence Position2-10
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Radiolabel; Mutation analysis
Interaction ID20159
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15014503
CommentsThe APCC-binding Destruction motif (DBox) due to which the human F-box protein Skp2 is polyubiquitinated, and hence earmarked for destruction, by APC(CDH1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)