Instance ID10160
Regular ExpressionxKENx
Motif InstanceSKENQ
Bait Uniprot AccessionQ12834
Bait Uniprot IdentifierCDC20_HUMAN
Bait Gene NameCDC20
Bait OrganismHomo sapiens (Human)
Sequence Position96-100
Critical ResiduesP2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning; Mutation analysis
Interaction ID20160
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10733526
CommentsAPCC-binding Destruction motif comprising a highly conserved KEN sequence (KEN Box) within human CDC20 that is preferentially recognised by the APC/C coactivator Cdh1 for recruitment to the APC/C complex leading to ubiquitination and proteasome-mediated degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)