Instance ID10161
Regular ExpressionxKENx
Motif InstanceKKENG
Bait Uniprot AccessionQ99741
Bait Uniprot IdentifierCDC6_HUMAN
Bait Gene NameCDC6
Bait OrganismHomo sapiens (Human)
Sequence Position80-84
Critical ResiduesP2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20161
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10995389
CommentsAPCC-binding Destruction motif comprising a highly conserved KEN sequence (KEN Box) within human CDC6 that is preferentially recognised by the APC/C coactivator CDH1 for APC-CDH1-dependent proteolysis of CDC6 in early G1 phase and in quiescent cells

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)