Instance ID10162
Regular ExpressionxKENx
Motif InstanceNKENY
Bait Uniprot AccessionO43683
Bait Uniprot IdentifierBUB1_HUMAN
Bait Gene NameBUB1
Bait OrganismHomo sapiens (Human)
Sequence Position534-538
Critical ResiduesP2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Ubiquitinase assay
Interaction ID20162
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17158872
CommentsFirst KEN-box motif (534-538) identified in the central region of human Bub1 that is the major degron involved in the degradation of Bub1 by the APC/C coactivator Cdh1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)