Instance ID10174
Regular ExpressionxKENx
Motif InstanceSKENV
Bait Uniprot AccessionO60566
Bait Uniprot IdentifierBUB1B_HUMAN
Bait Gene NameBUB1B
Bait OrganismHomo sapiens (Human)
Sequence Position25-29
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary Structure3(10)-helix
Experimental Method(s)X-ray crystallography; Mutation analysis
Interaction ID20174
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)23091007
CommentsCheckpoint inhibition of APC/C(Cdc20) requires the binding of the first BubR1 (BUB1B) KEN box (25-29) to Cdc20

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)