Instance ID10175
Regular Expressionx[ILM]R$
Motif InstanceGMR
Bait Uniprot AccessionP51955
Bait Uniprot IdentifierNEK2_HUMAN
Bait Gene NameNEK2
Bait OrganismHomo sapiens (Human)
Sequence Position443-445
Critical ResiduesP2; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Fluorescence microscopy; RNA interference; Mutation disrupting interaction; Co-IP; Mutation analysis; Immunodepleted Co-IP; Ubiquitinase assay;Western blot; Competition binding
Interaction ID20175
Interacting DomainTetratricopeptide repeats
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)23288039, 16648845
CommentsEarly mitotic degradation of NIMA-related kinase 2A (Nek2A) depends on an exposed carboxy-terminal methionine-arginine (MR) dipeptide tail that binds to the Tetratricopeptide repeats of CDC27

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)