Instance ID10189
Regular Expressionx[ILM]R$
Motif InstanceQIR
Bait Uniprot AccessionP53197
Bait Uniprot IdentifierCDH1_YEAST
Bait Gene NameCDH1
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position564-566
Critical ResiduesP2; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Tandem affinity purification; Mutation disrupting interaction; Mutation analysis; Pull down; Ubiquitinase assay; Alanine scanning; Radiolabel; comigration in non denaturing gel electrophoresis
Interaction ID20189
Interacting DomainTetratricopeptide repeats
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15916961, 19362536, 12574115
CommentsThe C-terminal IR tail motif in yeast CDH1 that mediates binding to the Tetratricopeptide repeats domain of the APC/C subunit Cdc27

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)