Instance ID10213
Regular Expressionx(S)xxF
Motif InstanceCSPQF
Bait Uniprot AccessionQ8WXE1
Bait Uniprot IdentifierATRIP_HUMAN
Bait Gene NameATRIP
Bait OrganismHomo sapiens (Human)
Sequence Position238-242
Critical ResiduesP2; P3; P4; P5
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureUnknown
Experimental Method(s)ITC; X-ray crystallography; Co-IP; Pull down
Interaction ID20213
Interacting DomainBRCT domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17616665, 24073851
CommentsPhosphorylated serine (pS) sequence in human ATR-interacting protein (ATRIP) that mediates a direct physical interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein and checkpoint function

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)