Instance ID10215
Regular Expressionx(S)xxF
Motif InstanceSSPVF
Bait Uniprot AccessionQ99708
Bait Uniprot IdentifierCOM1_HUMAN
Bait Gene NameRBBP8
Bait OrganismHomo sapiens (Human)
Sequence Position326-330
Critical ResiduesP2; P5
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureUnknown
Experimental Method(s)ITC; X-ray crystallography
Interaction ID20215
Interacting DomainBRCT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16101277
CommentsPhosphorylated serine (pS) sequence in human DNA endonuclease RBBP8 or CtIP that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, and the side chain of Arg1775 in the cancer-associated BRCA1 mutation M1775R sterically clashes with the phenyl ring of CtIP Phe330, disrupting the BRCA1-CtIP interaction

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)