Instance ID10217
Regular Expressionx(S)xxFxK
Motif InstanceTSPTFNK
Bait Uniprot AccessionQ9BX63
Bait Uniprot IdentifierFANCJ_HUMAN
Bait Gene NameBRIP1
Bait OrganismHomo sapiens (Human)
Sequence Position989-995
Critical ResiduesP2
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutation analysis; Pull down; SPR; ITC
Interaction ID20217
Interacting DomainBRCT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15125843, 14576433
CommentsPhosphorylated serine (pS) sequence (989-995) in human BRCA1-Associated Carboxyl-terminal Helicase (BACH1) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, which is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)