Instance ID10218
Regular Expressionx(S)xxY$
Motif InstanceASQEY
Bait Uniprot AccessionP16104
Bait Uniprot IdentifierH2AX_HUMAN
Bait Gene NameH2AFX
Bait OrganismHomo sapiens (Human)
Sequence Position139-143
Critical ResiduesP2; P5
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; ITC; Pull down; Mutation analysis
Interaction ID20218
Interacting DomainBRCT domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16377563
CommentsMDC1/NFBD1 directly binds to Histone H2AX (gammaH2AX) by specifically interacting with the phosphoepitope at the gammaH2AX carboxyl terminus through its BRCT repeat domain, this interaction playing a central role in the mammalian response to DNA damage

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)