Instance ID10239
Regular Expressionx[NP]W[DES]xW
Motif InstanceLPWDLW
Bait Uniprot AccessionP49418
Bait Uniprot IdentifierAMPH_HUMAN
Bait Gene NameAMPH
Bait OrganismHomo sapiens (Human)
Sequence Position380-385
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Western blot; Mutation analysis; X-ray crystallography; Classical fluorescence spectroscopy
Interaction ID20239
Interacting DomainClathrin propeller repeat
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11382783, 14981508, 10748223
Comments"Variant clathrin box motif (W box) in human Amphiphysin that are found in tandem arrangement with a ""classical"" clathrin box and cooperate to effect optimal clathrin binding and the formation of sedimentable assemblies"

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)