Instance ID10241
Regular Expression[DE][DE]xxxVP[DE]
Motif InstanceEEPQTVPE
Bait Uniprot AccessionP05412
Bait Uniprot IdentifierJUN_HUMAN
Bait Gene NameJUN
Bait OrganismHomo sapiens (Human)
Sequence Position227-234
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP
Interaction ID20241
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12615916
CommentsA consensus motif in human Transcription factor AP-1 (JUN) whose integrity is essential for the interaction with human E3 ubiquitin-protein ligase RFWD2 (or human COP1) causing suppression of AP-1-dependent transcription

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)