Instance ID10250
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceMRVTDFFSQSKRG
Bait Uniprot AccessionQ9I9A7
Bait Uniprot IdentifierCDT1_XENLA
Bait Gene Namecdt1
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position4-16
Critical ResiduesP11
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis
Interaction ID20250
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19595719
CommentsDocking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt3

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)