Instance ID10253
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRRVTDFFARRRP
Bait Uniprot AccessionQ9H211
Bait Uniprot IdentifierCDT1_HUMAN
Bait Gene NameCDT1
Bait OrganismHomo sapiens (Human)
Sequence Position4-15
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP
Interaction ID20253
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16861906
CommentsThe human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)