Instance ID10255
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceTSMTDFYHSKRRL
Bait Uniprot AccessionP38936
Bait Uniprot IdentifierCDN1A_HUMAN
Bait Gene NameCDKN1A
Bait OrganismHomo sapiens (Human)
Sequence Position145-157
Critical ResiduesP10; P11; P12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP
Interaction ID20255
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18703516, 18794347
CommentsPCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)