Instance ID10257
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRKLTDFYPVRRS
Bait Uniprot AccessionQ9NQR1
Bait Uniprot IdentifierSETD8_HUMAN
Bait Gene NameSETD8
Bait OrganismHomo sapiens (Human)
Sequence Position220-231
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay
Interaction ID20257
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20932472, 21220508
CommentsCDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)