Instance ID10258
Regular Expression[NQ]{0,1}xx[ILMV]T[DEN][HMFY][FMY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceNDITNYYKVKRRP
Bait Uniprot AccessionQ27368
Bait Uniprot IdentifierE2F_DROME
Bait Gene NameE2f
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position151-163
Critical ResiduesP3; P6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference; Mutation disrupting interaction; Fluorescence-activated cell sorting; Co-IP; Alanine scanning
Interaction ID20258
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19081076
CommentsS phase-specific destruction of Drosophila E2f1 is mediated by a PCNA-interacting-protein (PIP) motif in E2f1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)