Instance ID10260
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstanceGLDLSK
Bait Uniprot AccessionQ14526
Bait Uniprot IdentifierHIC1_HUMAN
Bait Gene NameHIC1
Bait OrganismHomo sapiens (Human)
Sequence Position241-246
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20260
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12052894
CommentsThe human candidate tumor suppressor gene HIC1 recruits CtBP through a conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)