Instance ID10262
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ99708
Bait Uniprot IdentifierCOM1_HUMAN
Bait Gene NameRBBP8
Bait OrganismHomo sapiens (Human)
Sequence Position490-494
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Competition binding
Interaction ID20262
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)E1A exon 2 peptide
Reference(s)9535825
CommentsHuman CtBP was found to specifically interact with human CtIP (CtBP-interacting protein) or DNA endonuclease RBBP8 through a conserved PLDLS motif and the CtBP-CtIP complex is disrupted by E1A resulting in tumorigenesis-restraining activity

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)