Instance ID10279
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ03112
Bait Uniprot IdentifierEVI1_HUMAN
Bait Gene NameMECOM
Bait OrganismHomo sapiens (Human)
Sequence Position584-588
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20279
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Chronic myeloid leukemia
Inhibitor(s)Unknown
Reference(s)11965542
CommentsThe t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP through the PxDLS motif

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)