Instance ID10285
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceKKLRF
Bait Uniprot AccessionP06400
Bait Uniprot IdentifierRB_HUMAN
Bait Gene NameRB1
Bait OrganismHomo sapiens (Human)
Sequence Position873-877
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC; X-ray crystallography; Mutation analysis
Interaction ID20285
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12501191, 9891042
CommentsThe cyclin recognition site (RxL motif) found in human Retinoblastoma-associated protein that interacts with Cyclin-A2 and thereby increases the specificity of phosphorylation by cyclin/CDK complexes

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)