Instance ID10287
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceRRLDL
Bait Uniprot AccessionQ01094
Bait Uniprot IdentifierE2F1_HUMAN
Bait Gene NameE2F1
Bait OrganismHomo sapiens (Human)
Sequence Position90-94
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; Pull down
Interaction ID20287
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12501191, 9199321
CommentsThe human transcription factor E2F-1 interacts stably with cyclin A via a cyclin recognition site (RxL motif) thus being negatively regulated by the cyclin A-dependent kinases

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)