Instance ID10293
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceRNLF
Bait Uniprot AccessionP46527
Bait Uniprot IdentifierCDN1B_HUMAN
Bait Gene NameCDKN1B
Bait OrganismHomo sapiens (Human)
Sequence Position30-33
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC; X-ray crystallography; Mutation analysis
Interaction ID20293
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12501191, 8684460, 9488039
CommentsThe cyclin recognition site (RxL motif) found in human cyclin-dependent kinase inhibitor p27Kip1 (CDKN1B) required for p21 interaction with cyclin E/Cdk2

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)