Instance ID10295
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceKKLMF
Bait Uniprot AccessionP04637
Bait Uniprot IdentifierP53_HUMAN
Bait Gene NameTP53
Bait OrganismHomo sapiens (Human)
Sequence Position381-385
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Mutation analysis; ITC; X-ray crystallography; Overlapping binding peptide
Interaction ID20295
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10884347, 12501191
CommentsThe C-terminal regulatory domain of human cellular tumor antigen p53 contains a functional docking site for cyclin A that is shared between the tumour suppressor proteins pRb and p53

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)