Instance ID10299
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceRRLLF
Bait Uniprot AccessionP30304
Bait Uniprot IdentifierMPIP1_HUMAN
Bait Gene NameCDC25A
Bait OrganismHomo sapiens (Human)
Sequence Position11-15
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20299
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)9234691
CommentsThe cyclin-binding RxL motif near the N terminus of human Cdc25A that mediates the association of Cdc25A with cyclin E and selectively interferes with the dephosphorylation of cyclin E-cdk2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)