Instance ID10302
Regular Expression[RK]xLx{0,1}[FYLIVMP]
Motif InstanceRELFI
Bait Uniprot AccessionP39880
Bait Uniprot IdentifierCUX1_HUMAN
Bait Gene NameCUX1
Bait OrganismHomo sapiens (Human)
Sequence Position1301-1305
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down(GST tag)
Interaction ID20302
Interacting DomainCyclin, N-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11584018
CommentsThe cyclin-binding RxL motif in human Homeobox protein cux-1 or CCAAT displacement protein (CDP) that is required for its interaction with Cyclin A-Cdk Complex resulting in the phosphorylation of CDP/Cux by cyclin A-Cdk1, which contributes to down-modulate CDP/Cux activity as cells progress into the G(2) phase of the cell cycle

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)