Instance ID10413
Regular ExpressionYxxxxL[VILMF]
Motif InstanceYDRKFLL
Bait Uniprot AccessionO60516
Bait Uniprot Identifier4EBP3_HUMAN
Bait Gene NameEIF4EBP3
Bait OrganismHomo sapiens (Human)
Sequence Position40-46
Critical ResiduesP1; P6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20413
Interacting DomainEukaryotic initiation factor 4E
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10394359, 9593750
CommentsThe eIF4E binding motif found in human 4E-BP3, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)