Instance ID10415
Regular ExpressionYxxxxL[VILMF]
Motif InstanceYDRKFLM
Bait Uniprot AccessionQ13541
Bait Uniprot Identifier4EBP1_HUMAN
Bait Gene NameEIF4EBP1
Bait OrganismHomo sapiens (Human)
Sequence Position54-60
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)ITC; X-ray crystallography; Mutation analysis; Colocalization; Y2H
Interaction ID20415
Interacting DomainEukaryotic initiation factor 4E
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10394359, 10406811
CommentsThe eIF4E binding motif found in human 4E-BP1, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)