Instance ID10417
Regular ExpressionYxxxxL[VILMF]
Motif InstanceYTRSRLM
Bait Uniprot AccessionQ9VMA3
Bait Uniprot IdentifierCUP_DROME
Bait Gene Namecup
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position327-333
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20417
Interacting DomainEukaryotic initiation factor 4E
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14685270
CommentsThe eIF4E binding motif in Drosophila Cup protein that mediates its interaction with eIF4E, which blocks the binding of eIF4G to eIF4E and mediates an indirect interaction between Smaug and eIF4E, resulting in translational repression

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)