Instance ID10420
Regular ExpressionYxPPx[ILMV]R
Motif InstanceYIPPHLR
Bait Uniprot AccessionO00571
Bait Uniprot IdentifierDDX3X_HUMAN
Bait Gene NameDDX3X
Bait OrganismHomo sapiens (Human)
Sequence Position38-44
Critical ResiduesP1; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20420
Interacting DomainEukaryotic initiation factor 4E
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17667941
CommentsCandidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by directly interacting with the dorsal surface of eIF4E through the conserved eIF4E-binding motif

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)