Instance ID10464
Regular Expression[DE]HxY
Motif InstanceDHQY
Bait Uniprot AccessionQ01094
Bait Uniprot IdentifierE2F1_HUMAN
Bait Gene NameE2F1
Bait OrganismHomo sapiens (Human)
Sequence Position97-100
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis; Y2H
Interaction ID20464
Interacting DomainGalactose oxidase, central domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16633736, 17612494
CommentsThe human G1 phase regulator HCF-1 displays coactivator properties when bound to the E2F1 transcriptional activator, but full-length E2F1 has regions that can inhibit its own interaction with the HCF-1 Kelch domain, suggesting that E2F1 has a latent ability to associate with HCF-1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)