Instance ID10472
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePRVSL
Bait Uniprot AccessionQ13263
Bait Uniprot IdentifierTIF1B_HUMAN
Bait Gene NameTRIM28
Bait OrganismHomo sapiens (Human)
Sequence Position486-490
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPR; GFP tag; Competition binding; Co-IP; Western blot; Mutation analysis
Interaction ID20472
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10938122, 16637071, 10938122
CommentsHuman Nuclear corepressor KAP-1 (E3 SUMO-protein ligase TRIM28) interacts with heterochromatin protein 1alpha (HP1 alpha/CBX5) using a HP1-binding motif that interacts with an interface formed by dimerization of two chromoshadow domains in HP1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)