Instance ID10477
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceFYATFLIQEYFRKFKKRKEQ
Bait Uniprot AccessionQ13936
Bait Uniprot IdentifierCAC1C_HUMAN
Bait Gene NameCACNA1C
Bait OrganismHomo sapiens (Human)
Sequence Position1666-1685
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Alanine scanning; X-ray crystallography
Interaction ID20477
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16338416
CommentsHuman Ca2+-calmodulin binds to the hydrophobic IQ motif of the human cardiac Ca(v)1.2 calcium channel that is required for its Ca2+-dependent inactivation (CDI) and facilitation (CDF)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)