Instance ID10496
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVSAMVIQRAFRRHLLQRSL
Bait Uniprot AccessionQ14524
Bait Uniprot IdentifierSCN5A_HUMAN
Bait Gene NameSCN5A
Bait OrganismHomo sapiens (Human)
Sequence Position1902-1921
Critical ResiduesP7; P8; P9; P11; P12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence technology; Co-IP; Mutation analysis; NMR; Alanine scanning
Interaction ID20496
Interacting DomainEF hand
Disease Association(s)Brugada syndrome; Long QT syndrome
Inhibitor(s)Unknown
Reference(s)16505387, 21167176
CommentsThe ubiquitous calcium sensor protein calmodulin (CaM) binds to the human voltage-gated sodium channel NaV1.5 IQ motif

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)