Instance ID10512
Regular Expression[LM]YPxxx[LI][^P][^P][LI]
Motif InstanceLYPLTSLRSL
Bait Uniprot AccessionP04591
Bait Uniprot IdentifierGAG_HV1H2
Bait Gene Namegag
Bait OrganismHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Sequence Position483-492
Critical ResiduesP2; P3
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)SPR; ITC; Mutation analysis; X-ray crystallography
Interaction ID20512
Interacting DomainV-domain
Disease Association(s)Human immunodeficiency virus (HIV) infection
Inhibitor(s)Unknown
Reference(s)18066081
CommentsEfficient budding of retroviruses such as HIV-1 requires short peptide motifs, known as late domains, in the viral Gag protein, that recruits human ALIX (AIP1/PDCD6IP)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)