Instance ID10524
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRLQKGNLPV
Bait Uniprot AccessionQ16828
Bait Uniprot IdentifierDUS6_HUMAN
Bait Gene NameDUSP6
Bait OrganismHomo sapiens (Human)
Sequence Position64-73
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Mass spectrometry study of hydrogen/deuterium exchange; X-ray crystallography
Interaction ID20524
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10811804, 17046812, 16567630
CommentsMAPK docking motif in human Mitogen-activated protein kinase phosphatase 3 (MKP3/DUSP6) that mediates binding to human MAP kinase 1 (or ERK-2)


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)