Instance ID10548
Regular ExpressionPPxLI
Motif InstancePPPLI
Bait Uniprot AccessionO75376
Bait Uniprot IdentifierNCOR1_HUMAN
Bait Gene NameNCOR1
Bait OrganismHomo sapiens (Human)
Sequence Position1033-1037
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)NMR; ITC; Fluorescence polarization spectroscopy
Interaction ID20548
Interacting DomainMYND domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23372760, 17560331
CommentsN-CoR (NCOR1) recruitment by the MYND domain of AML1/ETO through the PPxLI motif (1033-1037) of N-CoR plays a key role in AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)