Instance ID10549
Regular ExpressionPPxLI
Motif InstancePPPLI
Bait Uniprot AccessionO75376
Bait Uniprot IdentifierNCOR1_HUMAN
Bait Gene NameNCOR1
Bait OrganismHomo sapiens (Human)
Sequence Position1033-1037
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)NMR; ITC; Fluorescence polarization spectroscopy
Interaction ID20549
Interacting DomainMYND domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23372760, 17560331
CommentsHuman DEAF-1 transcription regulation activity is mediated through its interaction with Nuclear receptor corepressor 1 (NCOR1) via its MYND domain that binds to the PPxLI motif (1033-1037) of N-CoR

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)