Instance ID10550
Regular ExpressionPPxLI
Motif InstancePPPLI
Bait Uniprot AccessionQ9Y618
Bait Uniprot IdentifierNCOR2_HUMAN
Bait Gene NameNCOR2
Bait OrganismHomo sapiens (Human)
Sequence Position1113-1117
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)NMR; ITC; Fluorescence polarization spectroscopy
Interaction ID20550
Interacting DomainMYND domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23372760, 17560331
CommentsSMRT(NCOR2) recruitment by the MYND domain of AML1/ETO through the PPxLI motif (1113-1117) of SMRT plays a key role in AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)