Instance ID10578
Regular Expression[^P]L[^P][^P]LL[^P]
Motif InstanceRLQKLLK
Bait Uniprot AccessionQ16881
Bait Uniprot IdentifierTRXR1_HUMAN
Bait Gene NameTXNRD1
Bait OrganismHomo sapiens (Human)
Sequence Position46-52
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Pull down(GST tag); Colocalization(Confocal microscopy); Competition binding
Interaction ID20578
Interacting DomainLigand-binding domain of nuclear hormone receptor
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15199063
CommentsThe NR box motif of human Thioredoxin reductase TR1 (TXNRD1/GRIM12) that is necessary for binding the human Estrogen receptor (ESR1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)