Instance ID10580
Regular Expression[IL]A(P)x{6,8}[FLIVM]x[FLIVM]
Motif InstanceLAPYIPMDDDFQL
Bait Uniprot AccessionQ16665
Bait Uniprot IdentifierHIF1A_HUMAN
Bait Gene NameHIF1A
Bait OrganismHomo sapiens (Human)
Sequence Position562-574
Critical ResiduesP3
Motif PTM(s)Hydroxylation at Pro-P3
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; SPR
Interaction ID20580
Interacting DomainVHL beta domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12050673, 12004076
CommentsIn normoxia, human Hypoxia-inducible factor 1-alpha (HIF1A) is hydroxylated at Pro-564 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) which leads to ubiquitination and proteasomal degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)