Instance ID10582
Regular Expression[IL]A(P)x{6,8}[FLIVM]x[FLIVM]
Motif InstanceLAPYISMDDDFQL
Bait Uniprot AccessionQ9Y2N7
Bait Uniprot IdentifierHIF3A_HUMAN
Bait Gene NameHIF3A
Bait OrganismHomo sapiens (Human)
Sequence Position490-502
Critical ResiduesP3
Motif PTM(s)Hydroxylation at Pro-P3
Secondary StructureUnknown
Experimental Method(s)Co-IP; Sequence based prediction
Interaction ID20582
Interacting DomainVHL beta domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12538644
CommentsHuman Hypoxia-inducible factor 3-alpha (HIF3A) 1-3 splice variants is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-492 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)