Instance ID10583
Regular Expression[IL]A(P)x{6,8}[FLIVM]x[FLIVM]
Motif InstanceLAPTPGDAIISLDF
Bait Uniprot AccessionQ99814
Bait Uniprot IdentifierEPAS1_HUMAN
Bait Gene NameEPAS1
Bait OrganismHomo sapiens (Human)
Sequence Position403-416
Critical ResiduesP3
Motif PTM(s)Hydroxylation at Pro-P3
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20583
Interacting DomainVHL beta domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)14691554, 17986458
CommentsHuman Hypoxia-inducible factor 2-alpha (HIF2A)/ Endothelial PAS domain-containing protein 1 (EPAS1) is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-405 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)