Instance ID10596
Regular Expressionxx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x
Motif InstanceFVPNVHAAEFVPS
Bait Uniprot AccessionQ8IYD1
Bait Uniprot IdentifierERF3B_HUMAN
Bait Gene NameGSPT2
Bait OrganismHomo sapiens (Human)
Sequence Position59-71
Critical ResiduesP10
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)SPR; ITC; Co-IP; X-ray crystallography
Interaction ID20596
Interacting DomainMLLE domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14685257, 18056425, 16554297, 20418951
CommentsThe PAM2 motif (59-71) in human Eukaryotic peptide chain release factor subunit 3b (ERF3B)/ G1 to S phase transition protein 2 homolog (GSPT2) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)