Instance ID10597
Regular Expressionxx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x
Motif InstanceFKFNTDAAEFIPQ
Bait Uniprot AccessionQ12986
Bait Uniprot IdentifierNFX1_HUMAN
Bait Gene NameNFX1
Bait OrganismHomo sapiens (Human)
Sequence Position11-23
Critical ResiduesP10
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down; Co-IP; Mass spectrometry; Affinity chromatography technology
Interaction ID20597
Interacting DomainMLLE domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17267499
CommentsHuman cytoplasmic Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) interacts with NFX1-123, a splice variant of Transcriptional repressor NFX1, through its N-terminal PAM2 motif, and this interaction is critical to hTERT regulation in HPV16 E6-expressing epithelial cells

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)