Instance ID10614
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceMQRSIMSFFHP
Bait Uniprot AccessionP18858
Bait Uniprot IdentifierDNLI1_HUMAN
Bait Gene NameLIG1
Bait OrganismHomo sapiens (Human)
Sequence Position1-11
Critical ResiduesP8; P9
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Co-IP; Pull down(GST tag)
Interaction ID20614
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9649448
CommentsThe PCNA binding PIP box motif in human DNA ligase 1 (LIG1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)